Induced pluripotent stem cells (iPS cells) are gradually becoming a household name. This technology makes it possible for adult cells to "rejuvenate" into stem cells, so it has extremely broad application prospects for regenerative medicine. However, researchers have been trapped by obstacles such as low induction rate, slow speed, and complicated composition of iPS cells.
Yesterday morning, the 3rd China Stem Cell Research Annual Conference and the 5th Guangzhou International Stem Cell and Regenerative Medicine Forum opened in Guangzhou. It is reported that the latest research results of experts have made this a reality, and the research is expected to be used to treat neurological diseases.
According to experts, some stem cell factors were introduced into cells isolated from the patient's urine by special means and cultured through a special induction medium, and the patient's urine cells were successfully induced and transformed into functional neural stem cells. These neural stem cells, which are transformed from urine cells, can be expanded in vitro and differentiate into mature neurons and keratinocytes in the human body under appropriate conditions. In further animal model transplantation experiments, it can survive well in the body and integrate into the host's brain environment.
It is reported that nerve injury and neurodegenerative diseases such as spinal cord injury, Parkinson's disease, brain injury, etc., due to poor regeneration of nerve cells, there is currently no effective treatment. By obtaining and transplanting patient-specific nerve cells, the patient can replace the nerve cells that have been damaged and lost function, so as to achieve the purpose of curing such neurological diseases. Under normal circumstances, it is difficult to obtain and expand the patient's own nerve cells in vitro for clinical treatment.
This research result effectively solves this problem, and provides highly practical technical means and approaches for obtaining patient-specific neural stem cells for transplantation therapy, and is expected to play an important role in future clinical applications.
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