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The researchers placed the mice in a labyrinthine space to observe their stress behavior patterns. They found that in an open and strong place, the mice would feel stressed and panic, and try to escape; when drugs or genetic means were used to inhibit the function of the mouse amygdala to produce neuropsin protein, they were the same Areas will no longer have similar stress behavior patterns. The researchers concluded that neuropsin protein activity determines the mice's ability to withstand stress, which in turn determines its stress behavior pattern.
The researchers believe that the neuropsin protein pathway in the human brain also plays the same role and determines the stress behavior pattern of the human. The discovery of this signaling pathway provides new possibilities for the prevention and treatment of stress-related mental illnesses, such as depression and trauma sequelae, and the development of practical interventions to control stress behaviors and Further research is needed.
In life, people face all kinds of stress every day. Some people are nervous and can face it calmly; some people are uneasy and suffer from mental illnesses such as depression and anxiety. The pathological mechanism behind this difference is unclear. A recent report published by an international research team in the journal Nature said that the activity of neuropsin protein in the human brain determines the pattern of stress behavior. This protein signaling pathway makes some people more vulnerable to stress.
The research team consists of neurological scientists from the United Kingdom, Japan and Poland. After four years of research, they found that when people feel stressed, the amygdala of the brain produces more neuropsin protein, which triggers a series of chemical reactions and then activates genes related to stress behavior mechanisms. Through experiments, the researchers demonstrated the relationship between the neuropsin protein pathway and stress behavior patterns.
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